You've never heard of the Millennium Falcon?

Originally, I was trying to wrap the breadcrumbs and filter-set UI elements into one item to save real-estate (perhaps I will post a shot of this earlier concept). However, the word on the street was that the paradigm was too dramatic a shift from how other apps in our suite were addressing filters.
Thus - the dropdown of dropdowns. Complex, but then - so is the medical informatics data that the user is going to be presented.

Note - this is technically still a "wireframe" - so the design of the elements will probably be refined.

Thoughts welcomed.